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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-465@lptms.universite-paris-saclay.fr
DTSTART:20161116T110000Z
DTEND:20161116T120000Z
DTSTAMP:20161010T142511Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-sandrine-morlot/
SUMMARY:Physics-Biology interface seminar: Sandrine Morlot - LPTMS\, salle 
 201\, 2ème étage\, Bât 100\, Campus d'Orsay - 16 Nov 16 11:00
DESCRIPTION:Deficient ribosome biogenesis is an early marker of cellular se
 nescence\nSandrine Morlot (IGBMC\, Strasbourg)\nNOTE THE NEW LOCATION (due
  to renovation work at LPS)\n\nSaccharomyces cerevisiae is a powerful mode
 l organism to study replicative aging as asymmetric division gives rise to
  an aging mother cell and a rejuvenated daughter cell [Mortimer and Johnst
 on 1959\, Egilmez and Jazwinski 1989]. However the cellular mechanisms con
 trolling replicative lifespan and the rejuvenation process are still poorl
 y understood partly due to the technical limitations of following individu
 al cells from birth to death. In this context\, we have developed a high-t
 hroughput microfluidic device to follow up to 3200 single cells in paralle
 l throughout their lifespan under the microscope. Thanks to this technolog
 y\, we have established a timeline of events occurring successively during
  cellular aging. We have observed that cells experience a sharp transition
  into senescence. Indeed yeasts divide regularly every 90 minutes until a 
 senescence entry point (SEP) which occurs after 20 generations. After this
  point\, cell cycles strongly slow down until death [Fehrmann et al. Cell 
 Reports 2013]. Furthermore we have measured that the SEP is preceded by an
  abrupt increase in the nuclear volume and more specifically in the size o
 f nucleolus. The nucleolus is the nuclear compartment where ribosome bioge
 nesis is initiated. This age-dependent nuclear defect is retained by the m
 other only\, as daughter cells recover a normal nucleus and nucleolus\, in
  agreement with the daughter cell rejuvenation paradigm. We have character
 ized that pre-ribosome particles accumulate in the nucleolus approximately
  10 hours before entering into senescence. Our analysis suggests that this
  deficiency in ribosome biogenesis triggers cellular senescence.\n
CATEGORIES:physbio,seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
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  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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