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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-827@lptms.universite-paris-saclay.fr
DTSTART:20220511T110000Z
DTEND:20220511T120000Z
DTSTAMP:20220425T141340Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-silvia-grigolon/
SUMMARY:Physics-Biology interface seminar: Silvia Grigolon - Salle des sém
 inaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 11 Mai 22 11:00
DESCRIPTION:Robustness in miRNA-based circuits\nSilvia Grigolon (Laboratoir
 e Jean Perrin\, Sorbonne U.)\nPhenotypic differentiation often relies on b
 imodal distributions of gene expression levels\, which can normally be ach
 ieved by different molecular mechanisms. During the past decades microRNAs
 \, small noncoding RNA molecules\, were found to downregulate the expressi
 on of preferred mRNA targets by sequestering and successively degrading th
 em\, thus influencing the level of gene expression. In this talk\, I will 
 show how miRNAs play an important role in filtering noise in gene expressi
 on. Starting from purely intrinsic noise\, I will talk about how this can 
 be buffered by miRNAs\, which yet become apparently inefficient in the pre
 sence of sources of extrinsic noise. I will then theoretically address the
  question on how microRNA-mediated regulation can induce the appearance of
  bimodal phenotypes. Our findings show that the presence of extrinsic nois
 e favours bimodal distributions. This suggests a simple mechanism for obta
 ining bimodal populations where the presence of extrinsic noise relaxes th
 e requirements on parameters fine tuning.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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