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TZID:Europe/Paris
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UID:1-317@lptms.universite-paris-saclay.fr
DTSTART:20150504T110000Z
DTEND:20150504T120000Z
DTSTAMP:20150424T065551Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-stephan-grill/
SUMMARY:Physics-Biology interface seminar: Stephan Grill - Moyen Amphi\, Bu
 ilding 510\, Université Paris-Saclay Orsay - 4 Mai 15 11:00
DESCRIPTION:Actomyosin Force Generation and Pattern Formation\nStephan Gril
 l (MPI-CBG Dresden)\nMorphogenesis is one of the great unknowns in Biology
 . Much is known about molecular mechanisms of regulation\, but little is k
 nown about the physical mechanisms by which an unpatterned blob of cells d
 evelops into a fully structured and formed organism. The actomyosin cortex
  is a thin layer underneath the cellular membrane that can self contract\,
  which drives many of the large-scale morphogenetic rearrangements that ar
 e observed during development. How this cortex reshapes and deforms\, and 
 how such morphogenetic processes couple to regulatory biochemical pathways
  is largely unclear. I will discuss two emergent physical activities of th
 e actomyosin cytoskeleton\, an active contractile tension and an active to
 rque\, both of which can serve to drive flows and large-scale chiral rotat
 ions of the actomyosin cytoskeleton. I will illustrate how active tension 
 drive flows\, how molecular constituents of the cortex affect flows\, and 
 how morphogenetic patterns can be formed by coupling regulatory biochemist
 ry to active cortical mechanics. A particular focus will be the investigat
 ion of how compressive cortical flow drives the formation of an actin fila
 ment alignment pattern  for generating a cleavage furrow for cytokinesis.
CATEGORIES:seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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