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TZID:Europe/Paris
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UID:0-1098@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20260612T110000
DTEND;TZID=Europe/Paris:20260612T120000
DTSTAMP:20260529T145905Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-tatiana-morozova/
SUMMARY:Physics-Biology Interface seminar: Tatiana Morozova - Salle des sé
 minaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 12 Juin 26 11:00
DESCRIPTION:Tatiana Morozova &amp\; Fran Toplek (ENS Lyon - joint talk)\n\n
 Disordered Proteins: Insights from Polymer Physics\n\n\nThe phase separati
 on of intrinsically disordered proteins (IDPs)\, leading to the formation 
 of biomolecular condensates\, has attracted considerable attention because
  of its central role in cellular organisation and function\, as well as it
 s potential for biomaterial applications. Using state-of-the-art atomistic
  simulations\, I will demonstrate that disordered proteins can exhibit mar
 kedly different polymer-like behaviours—ranging from coil-like to globul
 e-like states—across different regions of their free-energy landscape\, 
 using β-casein as an example. In addition\, by combining molecular dynami
 cs simulations with quasi-elastic neutron scattering experiments\, I will 
 show how dense protein assemblies behave as self-crowded microenvironments
  that give rise to anomalous\, non-Fickian diffusion and heterogeneous dyn
 amics. These results provide molecular-level insight into how macromolecul
 ar organisation governs transport processes within biomolecular condensate
 s. Finally\, I will discuss strategies for extending simulations toward la
 rge-scale assemblies of IDPs using the  coarse-grained force field.\n\n\nS
 tructure-Based Approaches to Data-Driven Protein Folding\, Aggregation\, a
 nd Self-Assembly\n\nMulti-eGO is a data-informed modelling framework based
  on structure-based models with an added Bayesian touch. As a semi-transfe
 rable model\, it can be applied to a variety of biomolecular systems whene
 ver experimental or high-resolution molecular dynamics data are available\
 , enabling the construction of simplified yet efficient force fields. This
  allows the study of assembly processes and out-of-equilibrium protein dyn
 amics at quasi-atomic resolution and extended timescales.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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TZID:Europe/Paris
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DTSTART:20260329T030000
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