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TZID:Europe/Paris
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UID:0-689@lptms.universite-paris-saclay.fr
DTSTART:20191120T133000Z
DTEND:20191120T143000Z
DTSTAMP:20191019T202921Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-tuomas-knowles/
SUMMARY:Physics-Biology interface seminar: Tuomas Knowles - Salle des sémi
 naires du FAST et du LPTMS\, bâtiment Pascal n°530 - 20 Nov 19 13:30
DESCRIPTION:Probing proteins in small volumes\nTuomas Knowles (Cambridge Un
 iversity\, UK)\nWarning: special time\nThis talk outlines our efforts on e
 xploring experimental strategies to provide a new window into protein self
 -assembly that are enabled by operation in small volumes. We have shown th
 at microconfinement achieved through droplet microfluidics allows the isol
 ation of single nucleation events in protein aggregation and thus to study
  a rare event as single molecule resolution. Using this strategy we have a
 lso been able to develop an understanding of how aberrant misfolded protei
 n states are transmitted from one molecule to another through time and spa
 ce. More recently we have exploited measurements of mass transport through
  fluid streams under laminar flow conditions to generate a platform for pr
 obing protein-protein interactions under fully native conditions.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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