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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-310@lptms.universite-paris-saclay.fr
DTSTART:20150615T110000Z
DTEND:20150615T120000Z
DTSTAMP:20150610T192827Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-xavier-trepat/
SUMMARY:Physics-Biology interface seminar: Xavier Trepat - Moyen Amphi\, Bu
 ilding 510\, Université Paris-Saclay Orsay - 15 Juin 15 11:00
DESCRIPTION:Control of collective cell dynamics by adhesion\, tension and f
 racking\nXavier Trepat (ICREA @ Institute for Bioengineering of Catalonia 
 (IBEC)\, Barcelona)\nA broad range of biological processes such as morphog
 enesis\, tissue regeneration\, and cancer invasion depend on the collectiv
 e dynamics of epithelial cells. Such dynamics are determined by an exquisi
 te balance between intercellular adhesion\, cytoskeletal tension\, and int
 racellular pressure. To study this balance in a fully quantitative manner 
 I will present new techniques to map physical forces between and within ce
 lls. Using these techniques we studied how cellular forces are regulated a
 nd transmitted by the proteins that comprise intercellular adhesion comple
 xes. To do so\, we perturbed the main molecular players of the intercellul
 ar adhesome using RNAi and studied how these perturbations impact physical
  forces and cellular velocities in epithelial cell collectives. We found t
 hat perturbations targeting adherens junctions\, but also tight junctions\
 , gap junctions\, and desmosomes have a significant impact on cell velocit
 ies\, cell deformations\, cell-matrix traction forces\, and cell-cell forc
 es. We developed a cross-validation analysis to show that concentrations o
 f cell-cell adhesion proteins are significant predictors of cell-cell forc
 es. Finally\, I will discuss the determinants of epithelial integrity in t
 he presence of stretching and transepithelial pressure.
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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