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TZID:Europe/Paris
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UID:0-890@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20231010T110000
DTEND;TZID=Europe/Paris:20231010T120000
DTSTAMP:20231003T131647Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-alessandra-carbone-sorbonne-university/
SUMMARY:Séminaire du LPTMS : Alessandra Carbone (IBPS Sorbonne) - Salle de
 s séminaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 10 Oct 23 11
 :00
DESCRIPTION:The complexity of protein interactionsAlessandra Carbone (Sorbo
 nne University\, CNRS) I will describe two facets of the interaction of p
 roteins with other biological molecules. Firstly\, I will define soft diso
 rdered (flexible\, amorphous\, or intrinsically disordered) regions in a p
 rotein with increasing numbers of bound interactors and analyze the correl
 ation between disorder\, interfaces and assembly. Secondly\, I will addre
 ss the question of reconstructing\, ab initio\, protein-protein interactio
 n networks from protein language models and Neural Networks (NN) with memo
 ry from sequences with SENSE-PPI. SENSE-PPI addresses interactions between
  protein sequences\, possibly intrinsically disordered\, belonging to a mo
 del or non-model organism\, or to different species such as human and viru
 ses. References: K.Volzhenin\, L.Bittner\, A.Carbone\, SENSE-PPI reconst
 ructs protein-protein interactions of various complexities\, within\, acro
 ss\, and between species\, with sequence-based evolutionary scale modeling
  and deep learning\, BIORXIV/2023/558413 B. Seoane\, A. Carbone\, Soft di
 sorder modulates the assembly path of protein complexes\, PLoS Computation
 al Biology\, 2022. B.Seoane\, A.Carbone. The complexity of protein intera
 ctions unravelled from structural disorder\, PLoS Computational Biology\, 
 2021 
CATEGORIES:seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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TZID:Europe/Paris
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