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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-457@lptms.universite-paris-saclay.fr
DTSTART:20161006T110000Z
DTEND:20161006T120000Z
DTSTAMP:20160914T052113Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-armita-nourmohammad-seminaire-exceptionnel/
SUMMARY:Séminaire du LPTMS: Armita Nourmohammad  *** séminaire exceptionn
 el *** - LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay - 6 
 Oct 16 11:00
DESCRIPTION:Statistical physics of molecular evolution: from gene regulatio
 n to immune system\nArmita Nourmohammad (Lewis Sigler Institute\, Princeto
 n University)\nMolecular phenotypes\, such as gene expression or protein b
 inding affinities are important targets of natural selection\, and are oft
 en subject to time-dependent pressure form the environment. However\, the 
 map between encoding DNA sequences and molecular phenotypes is often too d
 ifficult to quantify. In this talk\, I will show that universality is an e
 merging property of complex phenotypes\, which are encoded by multiple gen
 omic loci. I will introduce a non-equilibrium framework for adaptive dynam
 ics of such phenotypes in time-dependent environments\, and between co-ev
 olving populations. In time-dependent environments\, changes in the enviro
 nment drive the evolution of the species\, but not vice versa. As an examp
 le\, I will present strong evidence that adaptation dominates the evolutio
 n of gene expression levels in Drosophila. Co-evolving populations recipro
 cally affect the fitness of each other\, acting as time-dependent environm
 ents with feedback. As an example\, I will show evidence of co-adaptation 
 between interacting cellular populations of HIV viruses and the antibody r
 epertoire of a patient over the course of an infection. In particular\, I 
 discuss the conditions for emergence of broadly neutralizing antibodies\, 
 which are recognized as critical for designing an effective vaccine agains
 t HIV.
CATEGORIES:seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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