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TZID:Europe/Paris
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UID:0-1095@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20260217T110000
DTEND;TZID=Europe/Paris:20260217T120000
DTSTAMP:20260211T104402Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-federica-ferretti-u-chicago/
SUMMARY:Séminaire du LPTMS: Federica Ferretti (U Chicago) - Salle des sém
 inaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 17 Fév 26 11:00
DESCRIPTION:Modeling emergent phenomena in adaptive immunity: from stereoty
 ped immunodominance to 'implicit regularization’ in antibody evolution: 
 Federica Ferretti ( NITMB\, Chicago)\n\n\nAbstract: The immune system is a
  complex\, self-organized\, very dynamic biological system\, which must op
 erate reliably and reproducibly to protect organisms from threats. This ro
 bustness is mediated by the statistical and biophysical aspects of the var
 ious processes of interest: in this sense\, it can be seen as an emergent 
 property. In this talk\, I will focus on two aspects of antibody evolution
  where quantitative approaches based on statistical and dynamical modeling
  can provide a useful description\, and help establish a link between micr
 oscopic mechanisms and emergent biological function.\nI will first introdu
 ce the problem of antibody immunodominance\, and propose a new quantitativ
 e framework to characterize the phenomenon. This framework is based on a s
 imple population dynamics model\, which can be mapped to a parabolic Ander
 son model on structured landscapes.\nI will then briefly discuss the theor
 etical study of a mechanism of `implicit regularization’ in population d
 ynamics\, inspired by antibody evolution in heterogeneous lymph-node envir
 onments. This mechanism is abstracted into an 'annealed population heterog
 eneity’\, which can be thought of as a population-wide implementation of
  the mini-batching strategy used in machine learning. Like in ML\, this pr
 oduces an inductive bias that favors the selection of generalist antibodie
 s—a major goal in the design of immunization strategies and development 
 of therapeutic antibodies.
CATEGORIES:seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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DTSTART:20251026T020000
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