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UID:0-915@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20240109T110000
DTEND;TZID=Europe/Paris:20240109T120000
DTSTAMP:20240104T100930Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-florian-goirand-tum-munich/
SUMMARY:Séminaire du LPTMS : Florian Goirand (TUM Munich) - Salle des sém
 inaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 9 Jan 24 11:00
DESCRIPTION:Structure-Function Interplay in Biological NetworksFlorian Goir
 and (TUM Munich)\nLiving matter exhibits properties that are commonly foun
 d to be shared far more widely than just among different individuals of th
 e same species. The ubiquity of these properties makes it possible to inve
 stigate in model systems elementary processes that belong to more complex 
 phenomena and for systems where biological data are lacking. Yet\, the und
 erstanding of the fundamental mechanisms that lead to their emergence is s
 till an active field of research. In particular\, deciphering the relation
 ship between the structure and function(s) of evolving systems has been th
 e subject of numerous studies\, even recently. Indeed\, if infering the im
 pact of the system structure on the realization of a given task is relativ
 ely straightforward\, it is much less obvious to consider task performance
  as the main driver of the emergence of structure and dynamics. However\, 
 the latter approach\, pioneered by Murray nearly a century ago\, has prove
 d to be relevant for successfully predicting the emergence of geometric an
 d topological properties in many adaptive biological systems. Following bo
 th approaches\, we use numerical and analytical methods to investigate the
  relationship between structure and function in brain microvascular networ
 ks. First\, we show how structure drives properties in healthy and altered
  brain microvascular networks. In particular\, we focus on the response of
  the system to perturbations such as (micro)strokes in the context of earl
 y detecting and treating brain pathologies with novel therapeutic approach
 es. Second\, we present how function may contribute to the morphogenesis o
 f brain microvascular networks\, highlighting that fundamental topological
  properties of brain microvascular networks can emerge spontaneously from 
 a basic optimization process. Finally\, we present stimulating perspective
 s for future research\, stressing on two specific research directions. On 
 the one hand\, we discuss the possibility of designing microfluidic device
 s of function-driven tunable properties. On the other hand\, we propose me
 ans to investigate the robustness of the neurovascular couple\, seen as a 
 network of networks\, in the context of neurodegenerative diseases such as
  Alzheimer's.\n\n\n\n
CATEGORIES:seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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