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UID:0-666@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20190409T110000
DTEND;TZID=Europe/Paris:20190409T120000
DTSTAMP:20190329T115104Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-mathilde-badoual/
SUMMARY:séminaire du LPTMS: Mathilde Badoual and Christophe Deroulers - LP
 TMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay - 9 Avr 19 11:0
 0
DESCRIPTION:How modelling and statistical physics can contribute to underst
 and brain tumors?\nMathilde Badoual and Christophe Deroulers (IMNC)\nDiffu
 se low-grade gliomas are slowly-growing tumors. After tens of years\, they
  transform inexorably into more aggressive forms\, jeopardizing the patien
 t’s life.\nIn our team\, we combine mathematical modelling\, statistical
  physics and image analysis\, in order to have a better understanding of t
 he natural history of these tumors and their response to treatments.\nWe p
 resent here two projects:\nWe will start with the effect of radiotherapy o
 n gliomas. We developed a mathematical model that describes the evolution 
 of cell density in gliomas and their response to treatments such as radiot
 herapy. We will show how biological data and clinical data were used to de
 sign and validate the model\, and we will discuss the results of the model
 .\nThe second part of the talk will be about the collective behaviour of p
 recursor cells that are suspected to be at the origin of gliomas. In their
  "normal state"\, these cells proliferate and die in order to maintain a c
 onstant cell density all over the adult brain (homeostasis). We modelled t
 hese phenomena with a cellular automaton and we will show that in the case
 s of almost uniform conditions\, we observe oscillations\, but in the case
  of non-uniform conditions\, we observe intriguing phenomena such as propa
 gating waves\, spiral waves\, large transient oscillations\, and even popu
 lation extinction. We will also show how the appearance of an abnormal cel
 l can lead to the appearance of a glioma.
CATEGORIES:seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
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 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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