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BEGIN:VEVENT
UID:1-168@lptms.universite-paris-saclay.fr
DTSTART:20130903T110000Z
DTEND:20130903T120000Z
DTSTAMP:20130902T053645Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-maxim-imakaev/
SUMMARY:Séminaire du LPTMS: Maxim Imakaev - LPTMS\, salle 201\, 2ème éta
 ge\, Bât 100\, Campus d'Orsay - 3 Sep 13 11:00
DESCRIPTION:Three dimensional architecture of human chromosomes: from data 
 analysis to polymer models\nMaxim Imakaev\, MIT\nThe three-dimensional and
  physical organization of genomes within cells plays critical roles in reg
 ulating chromosomal processes\, including gene regulation\, DNA replicatio
 n\, and genome stability. A recently developed method\, Hi-C\, provides a 
 comprehensive whole-genome information about physical contacts between gen
 omic region. Analysis of these data has begun to reveal determinants of 3D
  genomic organization.\nChromosomes can be understood as long polymers. We
  use a combination of data analysis and polymer modelling to pinpoint main
  determinants of the 3D genomic organization in several studied organisms.
  We build polymer models based on the known or suggested principles of chr
 omosomal organization and validate them against the Hi-C data. In particul
 ar\, we have shown that yeast chromosomal organization can be well-describ
 ed by a star-polymer model. The model we developed is consistent with the 
 yeast Hi-C data\, microscopy observations and diffusion measurements of ye
 ast chromosomes.\nWe also study folding of the human chromosomes during me
 taphase\, which is vital for completion of cell division. Here\, polymer m
 odelling allowed us to discriminated between the two long-studied models o
 f metaphase chromosomes: "bottle-brush" model of loops emanating from a ce
 ntral scaffold\, and an hierarchical folding principle.
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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