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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-301@lptms.universite-paris-saclay.fr
DTSTART:20141125T110000Z
DTEND:20141125T120000Z
DTSTAMP:20141119T090627Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-mikhail-tamm/
SUMMARY:Séminaire du LPTMS: Mikhail Tamm - LPTMS\, salle 201\, 2ème étag
 e\, Bât 100\, Campus d'Orsay - 25 Nov 14 11:00
DESCRIPTION:Genome packing and fractal globules: some new developments\nMik
 hail Tamm (Physics department\, Moscow State University)\nThe idea that ge
 nome packing in a cell nucleus is to a large extent governed by topologica
 l constraints has been around for many years: the corresponding topologica
 lly controlled state\, known as a fractal globule\, was first predicted in
  the late 1980s. Recently with the development of the new experimental tec
 hniques\, especially the so-called Hi-C contact maps\, a lot of new eviden
 ce appeared concerning the statistics of the genome spatial structure. Thi
 s new data seems to support the fractal globule model\, and therefore it c
 aused a significant renewed interest in the physics of the fractal globule
  state in the recent years. In my talk\, I will overview the ideas behind 
 the fractal globule model and the current state of art in the theory of ge
 nome packing. After that\, I will discuss two more narrow questions we hav
 e been trying to develop recently. In particular\, first\, I will talk abo
 ut the fine structure of the Hi-C contact maps and possible ways to explai
 n it by combining the hierarchical folding intrinsic to the fractal globul
 e idea and the assumption about quenched block-copolymer structure of the 
 genome. Second\, I will discuss the dynamic of self-diffusion in the fract
 al globule and develop a scaling theory predicting it to be a subdiffusion
  with a scaling index 0.4. I will also discuss the implications of this re
 sult for the search processes in the fractal globule.
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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