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BEGIN:VEVENT
UID:1-478@lptms.universite-paris-saclay.fr
DTSTART:20170228T110000Z
DTEND:20170228T120000Z
DTSTAMP:20170124T201211Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-shlomi-reuveni/
SUMMARY:Séminaire du LPTMS: Shlomi Reuveni - LPTMS\, salle 201\, 2ème ét
 age\, Bât 100\, Campus d'Orsay - 28 Fév 17 11:00
DESCRIPTION:First Passage Under Restart \nShlomi Reuveni (Department of Sy
 stems Biology\, Harvard Medical School\, Boston)\n\nStopping a process in 
 its midst—only to start it all over again—may prolong\, leave unchange
 d\, or even shorten the time taken for its completion. Among these three p
 ossibilities the latter is particularly interesting as it suggests that re
 start can be used to expedite the completion of complex processes involvin
 g strong elements of chance. This turned out to be important in computer s
 cience where restart drastically improves performance of randomized algori
 thms\, but is not less relevant to many physical\, chemical\, and biologic
 al processes since restart is inherent to the stochastic Michaelis-Menten 
 reaction scheme and this is ubiquitous throughout the sciences. I will int
 roduce the problem of first passage under restart using the example of sim
 ple diffusion\, but will then explain why many unknowns compel us to gener
 alize to arbitrary first passage processes and restart mechanisms. This ha
 s recently led us to discover universal features of the problem which I wi
 ll derive and describe\, and the framework developed will also serve to ma
 ke the case for a much required paradigm shift in our understanding of enz
 ymatic catalysis and inhibition at the single-molecule level.\n\nReference
 s :\n\n\n	S. Reuveni\, M. Urbakh and J. Klafter\, Role of Substrate Unbind
 ing in Michaelis–Menten Enzymatic Reactions\, PNAS 111 (12)\, 4391 (2014
 ).\n	T. Rotbart\, S. Reuveni and M. Urbakh\, Michaelis-Menten Reaction Sch
 eme as a Unified Approach Towards the Optimal Restart Problem\, Phys. Rev.
  E 92\, 060101(R) (2015).\n	S. Reuveni\, Optimal Stochastic Restart Render
 s Fluctuations in First Passage Times Universal\, Phys. Rev. Lett. 116\, 1
 70601 (2016).\n	A. Pal and S. Reuveni\, First Passage Under Restart\, Phys
 . Rev. Lett. 118\, 030603 (2017).\n	T. Rotbart\, S. Reuveni and M. Urbakh\
 , Single-enzyme approach predicts natural emergence of inhibitor-activator
  duality\, bioRxiv 095562.\n
CATEGORIES:seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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