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UID:0-765@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20210323T110000
DTEND;TZID=Europe/Paris:20210323T120000
DTSTAMP:20210304T231732Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lptm
 s-valerio-sorichetti-lptms/
SUMMARY:Séminaire du LPTMS : Valerio Sorichetti (LPTMS) - LPTMS (100% onli
 ne seminar) - 23 Mar 21 11:00
DESCRIPTION:Nonequilibrium simulation of cytoskeletal proteins: assembly\, 
 bundling and gelation\nValerio Sorichetti (LPTMS)\n\nOnline seminar --- ZO
 OM Meeting ID: 996 5227 7025 -- Password: ask L. Mazza and D. Petrov --\n\
 nThe cytoskeleton of living cells is a dynamical network with an extremely
  rich behavior: it maintains the shape of the cell\, gives it resistance t
 o deformation\, allows it to deform and migrate and provides the structure
  necessary for intracellular transport. In order to gain a better understa
 nding of the biological role of the cytoskeleton\, it is fundamental to un
 derstand how it assembles\, how it remodels itself and which factors deter
 mines its structure.\n\nThe competition between filament bundling and elon
 gation is one of the key factors in determining the structure and mechanic
 al properties of the cytoskeleton. In order to capture this out-of-equilib
 rium process\, we simulate a system of "patchy" monomers which can bind ir
 reversibly to each other to form long filaments.\n\nWe first consider mono
 mers which interact via a simple isotropic excluded volume interaction in 
 addition to the patchy interaction. We study the assembly kinetics of the 
 filaments\, finding that the mean filament length increases linearly with 
 time\, and give a theoretical interpretation of this finding.\n\nSuccessiv
 ely\, we allow the monomers to stick reversibly to each other via isotropi
 c short-ranged interactions. We show that this simple model leads to a ver
 y rich range of different behaviors\, giving rise to filaments\, bundles\,
  and complex bundle networks\, depending on the thermodynamic parameters c
 onsidered
CATEGORIES:seminars
LOCATION:LPTMS (100% online seminar)\, LPTMS - Bâtiment Pascal n° 530 rue
  André Rivière - Université Paris-Saclay\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=LPTMS - Bâtiment Pascal n
 ° 530 rue André Rivière - Université Paris-Saclay\, Orsay\, 91405\, Fr
 ance;X-APPLE-RADIUS=100;X-TITLE=LPTMS (100% online seminar):geo:0,0
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TZID:Europe/Paris
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DTSTART:20201025T020000
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