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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-161@lptms.universite-paris-saclay.fr
DTSTART:20130718T110000Z
DTEND:20130718T121500Z
DTSTAMP:20130723T101936Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/seminaire-excepti
 onnel-du-lptms-paolo-malgaretti/
SUMMARY:Séminaire exceptionnel du LPTMS : Paolo Malgaretti - LPTMS\, salle
  201\, 2ème étage\, Bât 100\, Campus d'Orsay - 18 Juil 13 11:00
DESCRIPTION:Molecular motors: velocity speed-up\, bidirectional motion and 
 confinement-induced rectification\nPaolo Malgaretti (University of Barcelo
 na)\nThe energy-consuming motion of molecular  motors is responsible form
  many cellular tasks\, ranging from cargo transport\, cellular signalling 
 and cellular division. The performances of single motors are strongly affe
 cted by the environment in which they work. Variation in ATP concentration
 \, viscosity of the cytoplasm due to molecular crowding and motor-motor in
 teractions can strongly affect the overall performances of molecular motor
 s. Here I will focus on how the cytoplasm molecular motors move in affects
  single as well collective molecular motors dynamics. On one hand I will s
 how that\, due to their reduced sizes and velocities\, molecular motors mo
 ve in the low Reynolds regime where the large range of the hydrodynamic in
 teraction  lead to collective behaviour not captured by the rigid-couplin
 g picture. Such interaction lead to large velocity speed-up that can be up
  to two order of magnitude as compared to the single motor case[1]. On the
  other hand hydrodynamic coupling can lead to spontaneous symmetry breakin
 g when motors pulling on opposite direction act on the same cargo[2].\nOn 
 the other hand the high concentration of suspended molecules and proteins 
 in the cytoplasm as well as local geometrical confinement imposed by organ
 elles or large vesicles in suspension can affect molecular motors dynamics
 .\nI will show that the effective space motors can explore while moving al
 ong a filament lead to a local bias that\,  coupling to the motor intrins
 ic stepping mechanism\, provides an alternative route to control molecular
  motors velocity[3].\n[1] P. Malgaretti\, I. Pagonabarraga\, D. Frenkel ``
 Running  faster together: Huge Speed up of Thermal Ratchets due to Hydrod
 ynamic Coupling\, Phys. Rev. Lett. 109\, 168101 (2012)\n[2] P.Malgaretti\,
  I. Pagonabarraga\, J-F. Joanny\, in preparation\n[3] P.Malgaretti\, I. Pa
 gonabarraga\, J. M. Rubi\, Confined Brownian ratchets\, J. Chem. Phys. 138
 \, 194906 (2013)\n&nbsp\;
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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