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BEGIN:VEVENT
UID:1-423@lptms.universite-paris-saclay.fr
DTSTART:20160531T143000Z
DTEND:20160531T170000Z
DTSTAMP:20160531T070223Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/soutenance-de-the
 se-pierre-ronceray/
SUMMARY:Soutenance de thèse : Pierre Ronceray - IPN-batiment 100\, Auditor
 iurm - 31 Mai 16 14:30
DESCRIPTION:Active contraction in biological fiber networks\nLarge-scale fo
 rce generation is essential for biological functions such as cell motility
 \, embryonic development\, wound healing and muscle contraction. In these 
 processes\, forces generated at the molecular level by motor proteins are 
 transmitted by disordered fiber networks\, resulting in large-scale active
  stresses.  While fiber networks are well characterized macroscopically\,
  this stress generation by microscopic active units is not well understood
 . In this Thesis\, I present a comprehensive theoretical and numerical stu
 dy of force transmission in elastic fiber networks. I show that the linear
 \, small-force response of the networks is remarkably simple\, as the macr
 oscopic active stress depends only on the geometry of the force-exerting u
 nit. In contrast\, as non-linear buckling occurs around these units\, loca
 l active forces are rectified towards isotropic contraction\, making the l
 ocal geometry of force exertion irrelevant. This emergent contractility is
  amplified by non-linear force transmission through the network. This stre
 ss amplification is reinforced by the networks' disordered nature\, but sa
 turates for high densities of active units. Our predictions are quantitati
 vely consistent with experiments on reconstituted tissues and actomyosin n
 etworks\, and that they shed light on the role of the network microstructu
 re in shaping active stresses in cells and tissue.
CATEGORIES:seminars
LOCATION:IPN-batiment 100\, Auditoriurm\, 15 Rue Georges Clemenceau\, orsay
 \, France
GEO:48.698196;2.181773
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=IPN-batiment 100\, Auditoriurm:
 geo:48.698196,2.181773
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