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TZID:Europe/Paris
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UID:1-363@lptms.universite-paris-saclay.fr
DTSTART:20150619T130000Z
DTEND:20150619T170000Z
DTSTAMP:20150530T100615Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/soutenance-hdr-ma
 rtin-lenz/
SUMMARY:Soutenance HDR : Martin Lenz - LPTMS-batiment 100\, salle des conse
 ils - 19 Juin 15 13:00
DESCRIPTION:On the microstructure of active cellular processes\nEukaryotic 
 cells use a multitude of protein machines to regulate their own structure.
  In this thesis\, we study how the geometrical arrangement of these intera
 cting microscopic active elements sculpt the cell's own internal microstru
 cture and its membrane enclosure.\nWe first focus on the mechanisms genera
 ting actomyosin contractility\, a crucial driver of cell motion and organi
 zation. We question the current position of highly organized\, sarcomeric 
 contractility as the only possible mechanism to drive contractility. We pr
 opose an alternative mechanism\, and show that only it can account for the
  observed contractility of disordered actomyosin assemblies. It moreover y
 ields qualitatively new effects in intracellular force transmission\, incl
 uding stress reversal and amplification\, consistent with experimentally o
 bservations in fiber networks.\nWe next elucidate some of the mechanisms t
 hrough which the cell deforms and cuts its own membrane\, thus enabling ex
 changes with the extracellular medium as well as between its internal comp
 artments. We find that the function of the proteins responsible for this r
 emodeling is strongly influenced by the mechanics of the membrane\, and us
 e these effects to elucidate the modes of operation of proteins clathrin a
 nd dynamin\, as well as of protein complex ESCRT-III.
CATEGORIES:seminars
LOCATION:LPTMS-batiment 100\, salle des conseils\, 15 Rue Georges Clemencea
 u\, Orsay\, France
GEO:48.698200;2.181770
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 conseils:geo:48.698200,2.181770
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