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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-247@lptms.universite-paris-saclay.fr
DTSTART:20140523T140000Z
DTEND:20140523T150000Z
DTSTAMP:20140521T054623Z
URL:https://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-
 interface-seminar-marie-pierre-valignat/
SUMMARY:Physics-Biology interface seminar: Marie-Pierre Valignat - Amphi BL
 ANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 23 Ma
 i 14 14:00
DESCRIPTION:Leukocyte sensing of flow direction\nMarie-Pierre Valignat (Lab
 oratoire Adhésion Cellulaire et Inflammation\, Marseille)\nAs they leave 
 the blood stream and travel to lymph nodes or sites of inflammation\, leuk
 ocytes are captured by the endothelium and migrate along the vascular wall
  to permissive sites of transmigration. These processes are supposedly orc
 hestrated by chemical signals and take place under the influence of a stro
 ng hemodynamic shear stress. The role of flow on leukocyte crawling and ex
 travasation remains generally an unsolved question\, however crawling T ly
 mphocytes were recently reported in vivo and in vitro to orient against th
 e direction of flow and to move upstream like salmons in a river. This non
 -intuitive behavior is manifestly not a passive drift of cells pushed by t
 he flow\, and we sought here to clarify the origin\, role and mechanism of
  this upstream flow mechanotaxis behavior.
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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