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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-325@lptms.universite-paris-saclay.fr
DTSTART:20150127T110000Z
DTEND:20150127T120000Z
DTSTAMP:20150107T120618Z
URL:https://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lpt
 ms-jonas-ranft/
SUMMARY:Séminaire du LPTMS: Jonas Ranft - LPTMS\, salle 201\, 2ème étage
 \, Bât 100\, Campus d'Orsay - 27 Jan 15 11:00
DESCRIPTION:Dynamics of synaptic domains: scaffold-protein aggregation at t
 he postsynaptic membrane\nJonas Ranft\, Laboratoire de Physique Statistiqu
 e de l'ENS\nThe dynamic nature of synaptic receptor populations poses the 
 question of how the number of receptors can be reliably controlled in spit
 e of their continuous dynamic reorganization. Increasing evidence points t
 o the stabilizing role of submembranous scaffold clusters that are formed 
 by oligomerization of specific proteins. However\, it is not clear in turn
  how these scaffold clusters form\, what controls their sizes and what is 
 their lifetime as compared to the protein turnover they are themselves sub
 ject to. Here\, we investigate the dynamics of synaptic domains by studyin
 g a simplified model of the scaffold dynamics at the postsynaptic neuronal
  membrane. We find by using particle-based simulations\, as well as analyt
 ic calculations\, that for all parameter regimes\, the system eventually r
 eaches a non-equilbrium stationary state with a characteristic distributio
 n of cluster sizes. The typical cluster size scales with the turnover rate
  and depends on how the diffusive mobility of clusters varies with their s
 izes. Lateral desorption of scaffold molecules can give rise to a critical
  size below which clusters dissolve\, thus favoring a bimodal distribution
  of synapse sizes. The results provide a basis for the stability of cluste
 rs in the face of molecular noise\, which is a necessary requirement for l
 ong-term memory and learning.
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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