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TZID:Europe/Paris
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UID:1-273@lptms.universite-paris-saclay.fr
DTSTART:20141104T110000Z
DTEND:20141104T120000Z
DTSTAMP:20141017T132329Z
URL:https://www.lptms.universite-paris-saclay.fr/seminars/seminaire-du-lpt
 ms-sam-safran/
SUMMARY:Séminaire du LPTMS: Sam Safran - LPTMS\, salle 201\, 2ème étage\
 , Bât 100\, Campus d'Orsay - 4 Nov 14 11:00
DESCRIPTION:Non-linearities and interactions of cells with their mechanical
  environment\nSam Safran\nDept. Materials and Interfaces\, Weizmann Instit
 ute of Science\, Rehovot\, Israel\nMany experiments have shown that the el
 astic substrates upon which cells are placed or the extracellular matrix (
 ECM) in which cells reside in 3D can regulate cellular structure and funct
 ion. From fate “decision making” of stem cells to rigidity-driven moti
 on\, cells actively sense and transduce elastic signals\, which in turn de
 pends on the elastic properties of the substrate or ECM. We review experim
 ental evidence to demonstrate that cell structure and function is regulate
 d by its mechanical environment (the presence of other cells\, external st
 retch\, matrix rigidity) and present a generic\, theoretical model for ce
 ll response that combines mechanics and cell activity. We predict that eve
 n symmetric cells on or in isotropic substrates interact elastically\, in 
 contrast to the vanishing interactions for the case of “dead inclusions
 ” under these situations.  The theory is extended to the biologically r
 elevant case of “strain stiffening”\, non-linear \, elastic substrates
  where the local cell deformations are amplified far from their origin. Fi
 nally\, we show how cell deformations can orient the surrounding medium wh
 ich in turn\, can provide guidance cues for cell motility.
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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