A statistical model of intra-chromosome contact maps

L. Nazarov 1 M. V. Tamm 1, 2 S. K. Nechaev 2, 3, 4 V. A. Avetisov 2, 5

Soft Matter, Royal Society of Chemistry, 2015, pp.1019

The statistical properties of intra-chromosome maps obtained by a genome-wide chromosome conformation capture method (Hi-C) are described in the framework of the hierarchical crumpling model of heteropolymer chain with quenched disorder in the primary sequence. We conjecture that the observed Hi-C maps are statistical averages over many different ways of hierarchical genome folding, and show that the existence of quenched primary structure coupled with hierarchical folding can induce the observed fine structure of intra-chromosome contact maps.

  • 1. Physics Department
  • 2. Department of Applied Mathematics
  • 3. LPTMS – Laboratoire de Physique Théorique et Modèles Statistiques
  • 4. P. N. Lebedev Physical Institute
  • 5. The Semenov Institute of Chemical Physics
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