Physics-Biology interface seminar: David Bensimon


11:00 - 12:00

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Quantitative analysis of the somitogenetic wavefront

David Bensimon (LPS-ENS, Paris, France)


Somitogenesis is the process by which the anterio-posterior axis is segmented in all vertebrates thus defining the coordinate system that will serve for positioning of the appendices and organs. This process of segmentation is due to the interaction between a posterior moving wavefront of morphogens and a posterior located clock generating somites (segments) at regular times and places. The existence and characterization of the clock has been amply demonstrated. In this talk I will focus on the molecular network behind the wavefront. I will discuss the wavefront response to various perturbations and compare our observations with a model of this network.

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