Physics-Biology interface seminar: Olivier Rivoire


11:00 - 12:00

Chargement de la carte…

How history shapes geometry in a model of protein evolution

Olivier Rivoire (Laboratoire interdisciplinaire de Physique, UJF Grenoble)

The interactions between amino acids in a protein are heterogeneous but not arbitrary: they enable proteins to perform specific biochemical « functions ». Understanding these interactions may require, however, looking beyond current functional requirements, to the evolutionary history of proteins. I will illustrate this point with a simple statistical mechanics model, which I will motivate with observations and experiments on natural proteins. The model relates the parameters controlling the evolution of a protein to the organization of the interactions inside its structure.

Retour en haut