From cells to tissue: A continuum model of epithelial mechanics
Philippe Marcq (Institut Curie, Paris)
A continuum model of epithelial tissue mechanics is formulated using cellular-level mechanical ingredients and cell morphogenetic processes, including cellular shape changes and cellular rearrangements. This model incorporates stress and deformation tensors, which can be compared with experimental data. Focusing on the interplay between cell shape changes and cell rearrangements, we elucidate dynamical behavior underlying passive relaxation, active contraction-elongation, and tissue shear flow. Extensions of the model allow to incorporate additional ingredients, such as cell division, cell death, and cell motility.