Physics-Biology interface seminar: Simon Scheuring


11:00 - 12:00

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High-Speed Atomic Force Microscopy: The dawn of dynamic structural biochemistry

Simon Scheuring (INSERM & Aix-Marseille Université)

The advent of high-speed atomic force microscopy (HS-AFM [1]) has opened a novel research field for the dynamic analysis of single bio-molecules: Molecular motor dynamics [2,3] membrane protein diffusion [4], assembly [5] and conformational changes [6] could be directly visualized. Further developments for buffer exchange [7] and temperature control [8] during HS-AFM operation provide breakthroughs towards the performance of dynamic structural biochemistry using HS-AFM.

[1] Ando et al., Chem Rev. 2014 Mar 26;114(6):3120-88.
[2] Kodera et al., Nature. 2010 Nov 4;468(7320):72-6.
[3] Uchihashi et al., Science. 2011 Aug 5;333(6043):755-8.
[4] Casuso et al., Nat Nanotechnol. 2012 Aug;7(8):525-9.
[5] Chiaruttini et al., Cell. 2015 Nov 5;163(4):866-79.
[6] Ruan et al., 2016, in preparation
[7] Miyagi et al., Nat Nanotechnol. 2016, in press
[8] Takahashi et al., 2016, in preparation

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