Tri-Séminaire de Physique Statistique : David Holcman


14:30 - 16:00

LPTMS, salle 201, 2ème étage, Bât 100, Campus d'Orsay
15 Rue Georges Clemenceau, Orsay, 91405
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Analysis of superresolution data using Langevin equation. Brownian receptortrafficking on neuronal cells

David Holcman (Institut de Biologie, Ecole Normale Supérieure – IBENS)

 What is the basis of learning and memory in the brain? Neurons are the main players and synapses that are micro-contact between them play a critical role. How synapses are organized at a molecular level and what defines their synaptic strength at a molecular level remains unclear, although it is due to the combine effect of many molecules together. Thus the number of receptors and molecules must be well regulated. I will present here an integrative modeling approach of synaptic transmission that accounts for receptor dynamics and a novel method to extract local biophysical properties from thousands of individual trajectories obtained from superresolution microscopy data. This talk summarizes our long lasting effort in integrating key parameters involved in regulating synaptic transmission and plasticity.

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