Epithelial sheet morphologies
E. Hannezo, Institut Curie
Understanding morphogenesis during the development of the embryo requires an understanding of how mechanical forces coordinate to generate the macroscopic shape of organs. Although it is acknowledged that adhesion and mechanical forces play a crucial role in determining the morphology of a cell, a precise model remains elusive. We propose a simple theoretical model based on adhesion and acto-myosin generated forces to study the morphology of epithelial cells and the 3D topology of epithelial sheets.