Séminaire du LPTMS: Martin Evans


11:00 - 12:00

LPTMS, salle 201, 2ème étage, Bât 100, Campus d'Orsay
15 Rue Georges Clemenceau, Orsay, 91405

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Model of Antibiotic Action on Bacterial Growth

Martin Evans (University of Edinburgh, UK)

In this talk I will describe a simple  model for the growth of a  bacterial population under the challenge of ribosome-targetting  antibiotics. I shall endeavour to motivate why statistical physics lends itself to the study of bacterial dynamics. The model I will   discuss is statistical physics-like in that it makes a coarse-grained description of the growth process, reduced to three variables within the bacterial cell – the antibiotic concentration, the concentration of ribosomes bound to antibiotics and the concentration of unbound ribosomes. Remarkably the model can explain several observations concerning   antibiotic action and bacterial growth rate. In particular the growth-dependent bacterial susceptibility is controlled by a single, « universal » parameter and the extreme behaviours correspond to the phenomenological classification into bactericidal and bacteriostatic antibiotics. The predictions of the model are backed up by experimental studies.

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