Ginestra Bianconi 1, Davide Fichera 2, Silvio Franz 2, Luca Peliti 3
Journal of Statistical Mechanics: Theory and Experiment (2011) P08022
Several pathogens use evolvability as a survival strategy against acquired immunity of the host. Despite their high variability in time, some of them exhibit quite low variability within the population at any given time, a somehow paradoxical behavior often called the evolving quasispecies. In this paper we introduce a simplified model of an evolving viral population in which the effects of the acquired immunity of the host are represented by the decrease of the fitness of the corresponding viral strains, depending on the frequency of the strain in the viral population. The model exhibits evolving quasispecies behavior in a certain range of its parameters, ans suggests how punctuated evolution can be induced by a simple feedback mechanism.
- 1. Department of physics, Northeastern University,
- 2. Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS),
CNRS : UMR8626 – Université Paris XI – Paris Sud
- 3. Dipartimento di Scienze Fisiche,
Università degli studi di Napoli Federico II