Collagen and gelatin from sol to gel states for the synthesis of biomaterials
Gervaise Mosser (Laboratoire de Chimie de la Matière Condensée, Université Pierre et Marie Curie)
Collagen type I, the most abundant protein of connective tissues (bones, dermis, tendons, etc), is a macromolecular mesogen that can form lyotropic liquid-crystal phases. With this approach, our team works on elaborating several biomimetic biomaterials. However, the use of collagen can be hindered due to its price and the possibility to easily denature into gelatine and noticeably during sterilization processes. In this context, we wanted to determine whether collagen could be partially replaced by gelatine without modification of the overall hierarchical structure of the biomaterial.