Some aspects of immune cells mechanobiology: activation of T lymphocytes and parasite phagocytosis by macrophages
Pierre-Henri Puech (Adhesion and Inflammation Lab – Aix-Marseille Universités)
Surface proteins of cells which are implicated in cell recognition and adhesion are also subjected to forces, since the interactions with their partner is often occuring at the interface between two cells. The study of the roles of physical cues, such as forces, substrate mechanics and dynamics has lead to the emergence of mechanobiology. One idea is to dissect how these physical cues « help » the cells to read and interpret, sometimes react to, biochemical messages, a process known as mechanotransduction.
In this seminar, we will present why and how forces and mechanics are thought to be key regulators of immune cell recognition using our work using two biological models:
- the crucial step of T cell activation which leads to an efficient immune response
- the phagocytic response of macrophages to the parasite Toxoplasma Gondii, responsible of toxoplasmosis.