Séminaire exceptionnel du LPTMS: Serena Bradde


14:30 - 15:30

LPTMS, salle 201, 2ème étage, Bât 100, Campus d'Orsay
15 Rue Georges Clemenceau, Orsay, 91405
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Emergence of global patterns in bacterial growth: from single cells to communities

Serena Bradde, City University of New York

Understanding how phenomenological behaviors observed in biological systems emerge from molecular interactions of many individual units and how these interactions shape the response of living systems to a changing environment are  challenging questions which lie at the interface between multiple disciplines.

In this talk I will draw an example from the human gut microbiome, the full consortium of microbes living in association with the human gutRecent developments in DNA sequencing have made it possible to monitor how the compositions of microbial species change in time.

Analysis of healthy adults under antibiotic treatment showed that the gut microbiota could take several weeks to recover after treatment cessation. This suggests that the combination of inter-species and host-microbe interactions and external perturbations could lead to hysteresis phenomena. 

We investigate this possibility and propose an out of equilibrium stochastic model able to explain this phenomenon in terms of a first-order phase transition scenario. Our study reveals the importance of noise-activated dynamics in the recovery from antibiotic-perturbed states.  

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